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Irrespective of all latest therapeutic advances, a proportion of people will still fall short to respond and may be viewed as for curative therapy. At present, only allogeneic hematopoietic cell transplantation may be regarded as perhaps curative, but It's also connected to significant morbidity and mortality.
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have also been recurrently picked in small cohorts of patients soon after CIT.sixty three,sixty four Clonal evolution plays an important position don't just in resistance to CIT, but in addition to novel brokers. Indeed, different issue mutations are identified within the BTK
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See "Specific therapies in CLL: mechanisms of resistance and approaches for administration" on website page 471.
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